{"id":6902,"date":"2025-01-30T11:41:56","date_gmt":"2025-01-30T10:41:56","guid":{"rendered":"https:\/\/www.techscale.cz\/cs\/?p=6902"},"modified":"2025-01-30T11:57:09","modified_gmt":"2025-01-30T10:57:09","slug":"atomarni-antibiotika-vyvinuta-ceskymi-vedci-dokazi-celit-rezistenci-bakterii","status":"publish","type":"post","link":"https:\/\/www.techscale.cz\/cs\/2025\/01\/30\/atomarni-antibiotika-vyvinuta-ceskymi-vedci-dokazi-celit-rezistenci-bakterii\/","title":{"rendered":"Atom\u00e1rn\u00ed antibiotika vyvinut\u00e1 \u010desk\u00fdmi v\u011bdci dok\u00e1\u017e\u00ed \u010delit rezistenci bakteri\u00ed"},"content":{"rendered":"[vc_row type=“in_container“ full_screen_row_position=“middle“ column_margin=“default“ column_direction=“default“ column_direction_tablet=“default“ column_direction_phone=“default“ scene_position=“center“ text_color=“dark“ text_align=“left“ row_border_radius=“none“ row_border_radius_applies=“bg“ overflow=“visible“ overlay_strength=“0.3″ gradient_direction=“left_to_right“ shape_divider_position=“bottom“ bg_image_animation=“none“][vc_column column_padding=“no-extra-padding“ column_padding_tablet=“inherit“ column_padding_phone=“inherit“ column_padding_position=“all“ column_element_direction_desktop=“default“ column_element_spacing=“default“ desktop_text_alignment=“default“ tablet_text_alignment=“default“ phone_text_alignment=“default“ background_color_opacity=“1″ background_hover_color_opacity=“1″ column_backdrop_filter=“none“ column_shadow=“none“ column_border_radius=“none“ column_link_target=“_self“ column_position=“default“ gradient_direction=“left_to_right“ overlay_strength=“0.3″ width=“1\/1″ tablet_width_inherit=“default“ animation_type=“default“ bg_image_animation=“none“ border_type=“simple“ column_border_width=“none“ column_border_style=“solid“][vc_column_text el_id=“perex“]\n

Unik\u00e1tn\u00ed cestu pro v\u00fdvoj antibiotik nov\u00e9 generace, kter\u00e1 jsou nejen \u00fa\u010dinn\u00e1 v\u016f\u010di \u0161irok\u00e9mu spektru bakteri\u00ed, ale dok\u00e1\u017e\u00ed spolehliv\u011b br\u00e1nit i rozvoji bakteri\u00e1ln\u00ed rezistence, objevili v\u011bdci z\u00a0Univerzity Palack\u00e9ho (UP) v Olomouci a Vysok\u00e9 \u0161koly b\u00e1\u0148sk\u00e9 \u2013 Technick\u00e9 univerzity Ostrava (V\u0160B-TUO) ve spolupr\u00e1ci s\u00a0kolegy z\u00a0\u010c\u00edny. V\u00a0\u00fa\u010dinn\u00e9 antibiotikum prom\u011bnili mangan, stopov\u00fd prvek nezbytn\u00fd pro lidsk\u00e9 t\u011blo, kter\u00fd ukotvili pomoc\u00ed atom\u00e1rn\u00edho in\u017een\u00fdrstv\u00ed ve struktu\u0159e chemicky upraven\u00e9ho grafenu. Testy na zv\u00ed\u0159ec\u00edch modelech prok\u00e1zaly, \u017ee nov\u00fd materi\u00e1l m\u00e1 obrovsk\u00fd potenci\u00e1l zejm\u00e9na v\u00a0lok\u00e1ln\u00ed terapii, nap\u0159\u00edklad p\u0159i hojen\u00ed ran. Objev\u00a0publikoval presti\u017en\u00ed \u010dasopis Advanced Materials<\/a>\u00a0a na ochranu materi\u00e1lu v\u011bdci podali evropsk\u00fd patent.<\/strong><\/h2>\n[\/vc_column_text][divider line_type=“No Line“ custom_height=“50″][vc_column_text]\n

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\u201eVyvinut\u00fd materi\u00e1l dok\u00e1\u017ee likvidovat a br\u00e1nit r\u016fstu v\u0161ech typ\u016f n\u00e1mi studovan\u00fdch bakteri\u00ed v\u010detn\u011b vysoce odoln\u00fdch patogen\u016f. Funguje v\u00a0n\u00edzk\u00fdch koncentrac\u00edch, p\u0159i kter\u00fdch je zcela ne\u0161kodn\u00fd v\u016f\u010di lidsk\u00fdm bu\u0148k\u00e1m. Bakterie nejsou schopny si v\u016f\u010di n\u011bmu vyvinout rezistenci, kter\u00e1 p\u0159edstavuje jeden z\u00a0nejv\u011bt\u0161\u00edch probl\u00e9m\u016f sou\u010dasn\u00e9 medic\u00edny. V\u0161echny tyto v\u00fdsledky jsou skv\u011bl\u00fdmi p\u0159edpoklady pro vyu\u017eit\u00ed atom\u00e1rn\u00edho antibiotika v\u00a0praxi,\u201c uvedl fyzik\u00e1ln\u00ed chemik a autor v\u00fdzkumn\u00e9ho konceptu Radek Zbo\u0159il p\u016fsob\u00edc\u00ed v\u00a0\u010cesk\u00e9m institutu v\u00fdzkumu a pokro\u010dil\u00fdch technologi\u00ed \u2013 CATRIN UP a Centru energetick\u00fdch a environment\u00e1ln\u00edch technologi\u00ed (CEET) na V\u0160B-TUO.<\/p>\n

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Front\u00e1ln\u00ed \u00fatok manganu<\/strong>
\nV\u011bdci p\u0159i v\u00fdvoji antibiotika z\u00faro\u010dili sv\u00e9 zku\u0161enosti z grafenov\u00e9 chemie a atom\u00e1rn\u00edho in\u017een\u00fdrstv\u00ed, jemu\u017e se v\u00a0posledn\u00edch letech intenzivn\u011b v\u011bnuj\u00ed. Tentokr\u00e1t vsadili na grafenov\u00fd deriv\u00e1t obohacen\u00fd atomy kysl\u00edku a dus\u00edku, do kter\u00e9ho chemicky zabudovali mangan \u2013 p\u0159echodn\u00fd kov, jen\u017e se v\u00a0lidsk\u00e9m t\u011ble pod\u00edl\u00ed na metabolismu, tvorb\u011b kost\u00ed, regulaci cukru v krvi \u010di ochran\u011b bun\u011bk p\u0159ed oxidativn\u00edm stresem.<\/p>\n

\u201eRozhodli jsme se za\u00fato\u010dit nikoliv na nejslab\u0161\u00ed, ale jedno z\u00a0nejsiln\u011bj\u0161\u00edch m\u00edst bakteri\u00ed \u2013 sacharidy v\u00a0jejich st\u011bn\u011b a bun\u011b\u010dn\u00e9 membr\u00e1n\u011b, kter\u00e9 jsou pro p\u0159e\u017eit\u00ed bakteri\u00ed kl\u00ed\u010dov\u00e9. Pln\u00ed mimo jin\u00e9 ochrannou funkci, zprost\u0159edkov\u00e1vaj\u00ed p\u0159enos l\u00e1tek i komunikaci s\u00a0okol\u00edm, slou\u017e\u00ed jako energetick\u00e9 rezervy bakteri\u00ed. D\u00edky tomu, \u017ee jsme chemicky nav\u00e1zali mangan na vybran\u00e9 skupiny sacharid\u016f, do\u0161lo k potla\u010den\u00ed jejich hlavn\u00edch funkc\u00ed a n\u00e1sledn\u00e9 bun\u011b\u010dn\u00e9 smrti. Z\u00e1sadn\u00ed je p\u0159itom role grafenov\u00e9ho nosi\u010de, kter\u00fd zabezpe\u010duje p\u0159enos iont\u016f manganu na povrch bakteri\u00ed a umo\u017en\u00ed jejich front\u00e1ln\u00ed chemick\u00fd \u00fatok na sacharidov\u00e9 molekuly,\u201c objasnil nov\u00fd p\u0159\u00edstup Zbo\u0159il.<\/p>\n

 <\/p>\n

P\u016fsob\u00ed i na nejv\u00edce rezistentn\u00ed bakterie<\/strong>
\nNov\u00fd materi\u00e1l je \u00fa\u010dinn\u00fd i proti bakteri\u00edm, na n\u011b\u017e st\u00e1vaj\u00edc\u00ed antibiotika nesta\u010d\u00ed. \u201eVynikaj\u00edc\u00ed baktericidn\u00ed efekt jsme prok\u00e1zali proti v\u0161em bakteri\u00edm z\u00a0takzvan\u00e9 skupiny ESCAPE, kter\u00e1 zahrnuje vysoce rezistentn\u00ed bakteri\u00e1ln\u00ed patogeny. Tyto bakterie jsou obzvl\u00e1\u0161t\u011b nebezpe\u010dn\u00e9, nebo\u0165 odol\u00e1vaj\u00ed b\u011b\u017en\u00fdm antibiotik\u016fm, co\u017e komplikuje l\u00e9\u010dbu a zvy\u0161uje riziko z\u00e1va\u017en\u00fdch infekc\u00ed zejm\u00e9na v\u00a0nemocni\u010dn\u00edm prost\u0159ed\u00ed. Atom\u00e1rn\u00ed antibiotikum bylo v\u00a0porovn\u00e1n\u00ed s\u00a0komer\u010dn\u00edmi antibiotiky jako jedin\u00e9 \u00fa\u010dinn\u00e9 proti v\u0161em rezistentn\u00edm bakteri\u00edm,\u201cobjasnil prvn\u00ed autor pr\u00e1ce David Pan\u00e1\u010dek z CATRIN UP a CEET V\u0160B-TUO.<\/p>\n

\u00da\u010dinek atom\u00e1rn\u00edho antibiotika v\u00fdzkumn\u00edci ov\u011b\u0159ili nejen v\u00a0laboratorn\u00edch podm\u00ednk\u00e1ch, ale ve spolupr\u00e1ci s\u00a0kolegy z\u00a0\u010c\u00edny i na my\u0161\u00edch modelech. \u201eP\u0159i in-vivo testech do\u0161lo k\u00a0velmi rychl\u00e9mu a efektivn\u00edmu hojen\u00ed ko\u017en\u00ed infekce zp\u016fsoben\u00e9 rezistentn\u00edm kmenem Staphylococcus aureus (zlat\u00fdm stafylokokem) a k dramatick\u00e9mu poklesu v\u0161ech z\u00e1n\u011btliv\u00fdch marker\u016f. Ji\u017e nyn\u00ed tak m\u016f\u017eeme uva\u017eovat o vyu\u017eit\u00ed nov\u00e9ho typu antibiotika pro kryt\u00ed ran nebo antibakteri\u00e1ln\u00ed \u00fapravy povrch\u016f um\u011bl\u00fdch materi\u00e1l\u016f. Zde vn\u00edm\u00e1me obrovsk\u00fd potenci\u00e1l z\u00a0hlediska mo\u017enosti potla\u010den\u00ed tvorby bakteri\u00e1ln\u00edch povlak\u016f nap\u0159\u00edklad na um\u011bl\u00fdch kloubn\u00edch n\u00e1hrad\u00e1ch, stentech nebo kanyl\u00e1ch. Nov\u00fd materi\u00e1l by i d\u00edky sv\u00e9mu mechanismu \u00fa\u010dinku mohl br\u00e1nit vzniku komplikuj\u00edc\u00edch infekc\u00ed, co\u017e by m\u011blo z\u00e1sadn\u00ed dopad na zdravotnictv\u00ed,\u201c \u0159ekl Milan Kol\u00e1\u0159, mikrobiolog a d\u011bkan L\u00e9ka\u0159sk\u00e9 fakulty UP, jen\u017e se na v\u00fdzkumu v\u00fdznamn\u011b pod\u00edlel.[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=“in_container“ full_screen_row_position=“middle“ column_margin=“default“ column_direction=“default“ column_direction_tablet=“default“ column_direction_phone=“default“ scene_position=“center“ text_color=“dark“ text_align=“left“ row_border_radius=“none“ row_border_radius_applies=“bg“ overflow=“visible“ overlay_strength=“0.3″ gradient_direction=“left_to_right“ shape_divider_position=“bottom“ bg_image_animation=“none“][vc_column column_padding=“no-extra-padding“ column_padding_tablet=“inherit“ column_padding_phone=“inherit“ column_padding_position=“all“ column_element_direction_desktop=“default“ column_element_spacing=“default“ desktop_text_alignment=“default“ tablet_text_alignment=“default“ phone_text_alignment=“default“ background_color_opacity=“1″ background_hover_color_opacity=“1″ column_backdrop_filter=“none“ column_shadow=“none“ column_border_radius=“none“ column_link_target=“_self“ column_position=“default“ gradient_direction=“left_to_right“ overlay_strength=“0.3″ width=“1\/1″ tablet_width_inherit=“default“ animation_type=“default“ bg_image_animation=“none“ border_type=“simple“ column_border_width=“none“ column_border_style=“solid“][image_with_animation image_url=“6905″ image_size=“full“ animation_type=“entrance“ animation=“None“ animation_movement_type=“transform_y“ hover_animation=“none“ alignment=““ border_radius=“10px“ box_shadow=“none“ image_loading=“default“ max_width=“100%“ max_width_mobile=“default“][\/vc_column][\/vc_row][vc_row type=“in_container“ full_screen_row_position=“middle“ column_margin=“default“ column_direction=“default“ column_direction_tablet=“default“ column_direction_phone=“default“ scene_position=“center“ text_color=“dark“ text_align=“left“ row_border_radius=“none“ row_border_radius_applies=“bg“ overflow=“visible“ overlay_strength=“0.3″ gradient_direction=“left_to_right“ shape_divider_position=“bottom“ bg_image_animation=“none“][vc_column column_padding=“no-extra-padding“ column_padding_tablet=“inherit“ column_padding_phone=“inherit“ column_padding_position=“all“ column_element_direction_desktop=“default“ column_element_spacing=“default“ desktop_text_alignment=“default“ tablet_text_alignment=“default“ phone_text_alignment=“default“ background_color_opacity=“1″ background_hover_color_opacity=“1″ column_backdrop_filter=“none“ column_shadow=“none“ column_border_radius=“none“ column_link_target=“_self“ column_position=“default“ gradient_direction=“left_to_right“ overlay_strength=“0.3″ width=“1\/1″ tablet_width_inherit=“default“ animation_type=“default“ bg_image_animation=“none“ border_type=“simple“ column_border_width=“none“ column_border_style=“solid“][vc_column_text]\n

<\/h3>\n

Atom\u00e1rn\u00ed antibiotikum otev\u00edr\u00e1 nov\u00e9 mo\u017enosti<\/strong>
\nV\u011bdeck\u00fd t\u00fdm bude ve v\u00fdzkumu pokra\u010dovat a materi\u00e1l testovat i pro syst\u00e9movou antibiotickou l\u00e9\u010dbu. \u201eSt\u00e1vaj\u00edc\u00ed antibiotika ji\u017e nedok\u00e1\u017e\u00ed l\u00e9\u010dit n\u011bkter\u00e9 z\u00e1va\u017en\u00e9 infekce a bakteri\u00e1ln\u00ed sepse jsou st\u00e1le \u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou \u00famrt\u00ed. Proto chceme ov\u011b\u0159it potenci\u00e1l atom\u00e1rn\u00edch antibiotik pro l\u00e9\u010dbu nejz\u00e1va\u017en\u011bj\u0161\u00edch bakteri\u00e1ln\u00edch onemocn\u011bn\u00ed,\u201c doplnil Kol\u00e1\u0159.<\/p>\n

Podle OSN lze odhadnout, \u017ee pokud se bude bakteri\u00e1ln\u00ed rezistence zvy\u0161ovat stejn\u00fdm tempem jako doposud, budou v roce 2050 nel\u00e9\u010diteln\u00e9 infekce vyvolan\u00e9 multirezistentn\u00edmi bakteriemi nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou \u00famrt\u00ed. Takzvan\u00e9 \u201esuperbakterie\u201c tak pro lidstvo p\u0159edstavuj\u00ed glob\u00e1ln\u00ed hrozbu, jej\u00edm\u017e \u0159e\u0161en\u00edm je pr\u00e1v\u011b v\u00fdvoj nov\u00fdch antibakteri\u00e1ln\u00edch l\u00e1tek schopn\u00fdch obej\u00edt st\u00e1vaj\u00edc\u00ed mechanismy, kter\u00e9 si bakterie na svoji ochranu vytv\u00e1\u0159ej\u00ed. \u00a0V\u00fdzkum v\u011bdeck\u00e9ho t\u00fdmu, na n\u011bm\u017e se pod\u00edleli tak\u00e9 kolegov\u00e9 z P\u0159\u00edrodov\u011bdeck\u00e9 fakulty UP a dvou \u010d\u00ednsk\u00fdch instituc\u00ed, tak potvrzuje netu\u0161en\u00fd potenci\u00e1l atom\u00e1rn\u00edho in\u017een\u00fdrstv\u00ed p\u0159i \u0159e\u0161en\u00ed jedn\u00e9 z\u00a0nejv\u011bt\u0161\u00edch v\u011bdeck\u00fdch a spole\u010densk\u00fdch v\u00fdzev.[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=“in_container“ full_screen_row_position=“middle“ column_margin=“default“ column_direction=“default“ column_direction_tablet=“default“ column_direction_phone=“default“ scene_position=“center“ text_color=“dark“ text_align=“left“ row_border_radius=“none“ row_border_radius_applies=“bg“ overflow=“visible“ overlay_strength=“0.3″ gradient_direction=“left_to_right“ shape_divider_position=“bottom“ bg_image_animation=“none“][vc_column column_padding=“no-extra-padding“ column_padding_tablet=“inherit“ column_padding_phone=“inherit“ column_padding_position=“all“ column_element_direction_desktop=“default“ column_element_spacing=“default“ desktop_text_alignment=“default“ tablet_text_alignment=“default“ phone_text_alignment=“default“ background_color_opacity=“1″ background_hover_color_opacity=“1″ column_backdrop_filter=“none“ column_shadow=“none“ column_border_radius=“none“ column_link_target=“_self“ column_position=“default“ gradient_direction=“left_to_right“ overlay_strength=“0.3″ width=“1\/1″ tablet_width_inherit=“default“ animation_type=“default“ bg_image_animation=“none“ border_type=“simple“ column_border_width=“none“ column_border_style=“solid“][nectar_video_lightbox link_style=“play_button_mouse_follow“ image_url=“6914″ mouse_indicator_style=“solid_color“ video_url=“https:\/\/youtu.be\/To-MaaT9wMw?feature=shared“][vc_custom_heading text=“author: Martin Pykal“ font_container=“tag:h3|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row][vc_row type=“in_container“ full_screen_row_position=“middle“ column_margin=“default“ column_direction=“default“ column_direction_tablet=“default“ column_direction_phone=“default“ scene_position=“center“ text_color=“dark“ text_align=“left“ row_border_radius=“none“ row_border_radius_applies=“bg“ overflow=“visible“ overlay_strength=“0.3″ gradient_direction=“left_to_right“ shape_divider_position=“bottom“ bg_image_animation=“none“][vc_column column_padding=“no-extra-padding“ column_padding_tablet=“inherit“ column_padding_phone=“inherit“ column_padding_position=“all“ column_element_direction_desktop=“default“ column_element_spacing=“default“ desktop_text_alignment=“default“ tablet_text_alignment=“default“ phone_text_alignment=“default“ background_color_opacity=“1″ background_hover_color_opacity=“1″ column_backdrop_filter=“none“ column_shadow=“none“ column_border_radius=“none“ column_link_target=“_self“ column_position=“default“ gradient_direction=“left_to_right“ overlay_strength=“0.3″ width=“1\/1″ tablet_width_inherit=“default“ animation_type=“default“ bg_image_animation=“none“ border_type=“simple“ column_border_width=“none“ column_border_style=“solid“][vc_custom_heading text=“V\u00fdzkum byl podpo\u0159en projekty TECHSCALE, 2D-BioPAD a REFRESH.“ font_container=“tag:h2|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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